Ayuna Longeva Epidermal Fasting Ampoules 12x 2ml

Clinically proven ampoules for cellular longevity and skin balance

Modern skin receives too much: too many active ingredients, too many products in a routine, too many signals to process. What initially works as good care ultimately disrupts the skin’s natural rest cycles. Just as the human body benefits from intermittent fasting to activate cellular repair, clinical research shows that the skin also needs structured rest periods to restore its own regenerative intelligence.

Ayuna Longeva is the world’s first treatment to translate the principle of epidermal fasting into a concrete ampoule cure, awarded a Top 10 Best Applied Research Award at the IFSCC congress in Cannes. The twelve glass ampoules contain a biotechnological concentrate with Vitis Fasting Factors — plant molecules from Vitis vinifera stem cell cultures grown under controlled nutrient deprivation. In this fasting state, the cells release exosomal resveratrol, 155 signaling peptides, and spermidine, molecules that activate the skin’s cellular longevity. Supplemented with the C5 BioCell® Complex, symbiotic ferments, and the Vagal Gesture application ceremony, this treatment addresses skin, nervous system, and emotional well-being simultaneously.

Benefits

• Clinically proven +21% elasticity, -14% wrinkles, and -27% redness after four weeks
• Activates cellular longevity via exosomal resveratrol and spermidine from Vitis fasting cells
• Maintains skin microbiome diversity and strengthens barrier function
• Lowers cortisol levels by 43.5% through the Vagal Gesture ceremony
• Restores texture, complexion, and radiance after seasonal changes, travel, or stress
• IFSCC Cannes Top 10 Award for applied scientific research

Active Ingredients

Botanical Fasting Factors (Vitis vinifera Flower Cell Extract): The heart of Longeva and a scientific breakthrough. Molecules are extracted from stem cell cultures of grapevine grown under controlled nutrient deprivation — a fasting-like state — which the cells produce themselves in response to stress. This hormetic biotechnology concentrates polyphenols, exosomal resveratrol, 155 signaling peptides, spermidine, and protective enzymes. The exosomes act as cellular messengers and restore skin homeostasis, while spermidine is known for its role in cellular longevity and autophagy.

C5 BioCell® Complex: A biotechnological fusion of five plant stem cell cultures — turmeric, centella asiatica, green root, Arabian cotton, and pomegranate. This combination stimulates skin regeneration, smoothness, and vitality at the cellular level and enhances the effect of the Vitis Fasting Factors. Turmeric contributes to pigment balance, centella to barrier repair, green root to renewal, Arabian cotton to microbiota protection, and pomegranate to antioxidant defense.

Symbiotic ferment (Lactobacillus & coconut): A postbiotic ferment complex that supports the balance of the skin microbiome by nourishing beneficial flora and strengthening the epidermal barrier. Essential in a fasting treatment: where fewer ingredients are offered, the existing skin ecosystem must strengthen itself. The ferment refines texture, provides immediate comfort, and results in a visibly healthier complexion.

Sublimated lemon water: Obtained through upcycling of organic citrus fruit — a circular process combining respect for the planet with a mineral-rich hydrating base ingredient. The watery element of the formula is deliberately kept minimal to support the biocompatible galenic base without adding unnecessary substances.

Beautifulness aromachological cocktail: A 100% natural synergy of essential oils from gurjum, palo santo, myrrh, chamomile, rosemary, and buchu. The blend enhances the neuro-sensory dimension of the treatment and works together with the Vagal Gesture to activate alpha and theta brain waves, associated with calm, creativity, and meditation.

Biocompatible galenic base: A minimalist carrier composed of organic citrus biowater and natural humectants recognized by the skin as familiar. Free from synthetic fragrances, controversial preservatives, and unnecessary intermediates — perfectly fitting the fasting philosophy where every ingredient serves a purpose.

How to use

1. Choose your usage cycle: Intensive Reset (6 consecutive evenings), Complete Cure (12 ampoules per month), or Weekend Ritual (3 consecutive evenings)
2. Thoroughly cleanse the skin and create a moment of silence — the ritual begins with mindful preparation
3. Gently shake the ampoule, warm it between your palms, and break the neck with the included opener
4. Pour the contents into your palm, apply to face, neck, and décolleté with slow, circular motions until fully absorbed
5. Perform the Vagal Gesture: place both palms over the face, inhale for 4 seconds, hold for 2 seconds, exhale for 6 seconds — repeat three times
6. Finish by slowly moving your hands down to the neck and sternum; let the calm spread through your body
7. Ideally use 3 to 4 times per year during seasonal changes, after travel, or in stressful periods

Suitable for

• Adult and mature skin showing visible signs of fatigue and sagging
• Dull, congested skin that has lost its cellular vitality
• Stressed skin due to travel, seasonal changes, or intensive work periods
• All skin types, including sensitive skin (clinical research included 20 people with sensitive skin)
• Conscious lovers of luxury skincare who prioritize quality over quantity
• All ages and genders, tested clinically from 28 to 69 years old

Frequently Asked Questions

What exactly is epidermal fasting and why does it work?

Epidermal fasting is a new cosmetic discipline where the skin is consciously stimulated less to regain its own regenerative intelligence. Just as intermittent fasting in the body activates cellular cleanup processes like autophagy, a fasting treatment for the skin restores the natural rhythms of balance, detoxification, and renewal. Ayuna Longeva is the first product to clinically validate this principle — the scientific findings were awarded at the IFSCC congress in Cannes.

How often per year should I use Longeva for optimal results?

The ideal frequency is three to four times per year, aligned with moments when the skin needs extra support: seasonal changes, returning from travel, or intensive stressful periods. Choose the appropriate cycle each time: an Intensive Reset of six consecutive evenings, a Complete Cure of twelve ampoules spread over a month, or a Weekend Ritual of three consecutive evenings.

What is the Vagal Gesture and why is it part of this treatment?

The Vagal Gesture is a breathing and touch ritual that activates the vagus nerve — the nerve responsible for rest and recovery in the parasympathetic nervous system. Clinical research showed a 43.5% reduction in cortisol and an increase in alpha and theta brain waves after this application. For skincare, this means improved absorption of active ingredients, reduced inflammatory responses, and optimized repair capacity of skin cells. The Gesture is an integral part of the treatment — not decorative, but functionally proven.

Can I combine Longeva with other Ayuna products or should I simplify my routine?

Longeva works excellently with other Ayuna products that share the detoxification and renewal principle, such as Balm, Essence, or The Facial. However, it is recommended to simplify your daily routine during a Longeva cure — perfectly fitting the fasting principle. Continue using sun protection like Velo or Velo X in the morning, but temporarily skip other serums to allow the fasting effect to fully unfold.

When will I see results from Longeva?

Immediately after the first ampoule, a smoother and more radiant skin is visible due to the neuro-sensory effect of the Vagal Gesture and intensive hydration. Structural changes appear from three to four weeks: clinical studies with 66 women (28-69 years) showed after four weeks a 21% improvement in elasticity, 14% fewer wrinkles, and 27% less redness. The facial contour also became visibly more defined, confirmed by EvaFACE3D measurement.